Hacker News
Can eating high fat cheese and cream reduce dementia risk,as new study suggests?
bikenaga
|next
[-]
Abstract: "This study included 27,670 participants (mean baseline age 58.1 years, SD 7.6; 61% female). During a median of 25 years of follow-up, 3,208 incident dementia cases were recorded. Consumption of ≥50 g/d of high-fat cheese (>20% fat) was associated with a reduced risk of all-cause dementia (HR 0.87; 95% CI, 0.78–0.97) and VaD (HR 0.71, 95% CI 0.52–0.96) compared with lower intake (<15 g/d). An inverse association between high-fat cheese and AD was found among APOE ε4 noncarriers (HR 0.87, 95% CI 0.76–0.99, p-interaction = 0.014). Compared with no consumption, individuals consuming ≥20 g/d of high-fat cream (>30% fat) had a 16% lower risk of all-cause dementia (HR 0.84, 95% CI 0.72–0.98). High-fat cream consumption was inversely associated with the risk of AD and VaD. Consumption of low-fat cheese, low-fat cream, milk (high-fat and low-fat), fermented milk (high-fat and low-fat), and butter showed no association with all-cause dementia."
apothegm
|root
|parent
[-]
mfworks
|root
|parent
[-]
> Body mass index (BMI) was calculated from measured weight and height and categorized into 4 groups (<18.5, 18.5–24.9, 25–29.9, and ≥30 kg/m2). Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg, or the use of antihypertensive medication. Diabetes was identified through self-reported diagnosis, medication usage, and registry records. The intake of lipid-lowering drugs was self-reported. Baseline blood lipoproteins were only available in 4,549 participants and, therefore, not included as covariates. The APOE genotype was determined based on 2 single-nucleotide variants, rs429358 and rs7412, which define the ε2, ε3, and ε4 alleles. Participants carrying at least 1 ε4 allele were classified as APOE ε4 carriers.