Astro Hacker News - Comparing benefits of every-third-day vs. daily low-dose aspirin therapy (2001)

sathomasga |next [-]

Follow up in 2015 with essentially the same conclusions:

"Acetylsalicylic Acid Daily vs Acetylsalicylic Acid Every 3 Days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa, and Prostaglandin E2 Synthesis"

https://accp1.onlinelibrary.wiley.com/doi/abs/10.1002/jcph.6...

chr15m |root |parent [-]

Thanks for sharing this!

OptionOfT |next |previous [-]

I got prescribed 30 days of low-dose aspirin after my hip replacement to prevent clotting. 81mg. At least I didn't have side effects, the other anti-inflammatory made my brain foggy.

polishdude20 |next |previous [-]

What's the benefit of taking aspirin regularly anyways?

DougN7 |root |parent [-]

It’s supposed to help reduce clotting, and thus help a bit to prevent a heart attack, at least that’s what I understood from my heart doctor. Generally you’d take the 81mg “baby aspirins” for this, not a full adult dose.

Keyframe |root |parent [-]

or in this case one fizzy tablet every three days? Are tehre people doing this long term? Doesn't sound all that compatible with colon.

DougN7 |root |parent [-]

After a heart procedure my doctor told me to take the 81mg daily for the rest of my life. It’s been about 20 years now, with no side effects that I know of.

walterbell |next |previous [-]

This could mitigate side effects (stomach ulcers, bleeding) while retaining most of the benefits.

chr15m |root |parent |next [-]

Some research suggests the stomach bleed risk comes from the platelet inhibition itself, which would mean you can't have the good effect without the bad.

chr15m |root |parent [-]

Hang on, the 2015 study suggests otherwise.

Daily dose suppressed PGE2 while 3-daily dose didn't.

> Since PGE2 is involved in gastric healing, we understand that this new approach could be safer and as efficient as the standard daily therapy on a long-term basis.

abrookewood |root |parent |previous [-]

So in one case you get triple the daily dose (325 mg vs 81mg) every three days. I'm not sure how that would mitigate side effects?

walterbell |root |parent [-]

From the summary, only small difference between 81mg daily vs 81mg every 3 days, i.e 87% benefit at 33% averaged dosage.

  325mg every third day: 86% inhibition
  81mg per day:          85% inhibition
  81mg every third day:  74% inhibition

hn_throw2025 |next |previous [-]

I would recommend asking your medical practitioner about enteric-coated forms.

I am nearly nine months into NSAID gastritis from only a week of daily 75mg soluble Aspirin.

I have had more painful acute illnesses in the past, but the grind of a long-term illness is new to me and it has been absolutely terrible.

dzdt |previous [-]

Is there a good heuristic now for which things on nih.gov.or cdc.gov are real science?

illini1 |root |parent [-]

This is a paper published from 2001 with no bearing on the current political climate.

Dwedit |root |parent [-]

The concern is whether the file is unaltered from its original 2001 release.

walterbell |root |parent [-]

Source PDF with identical summary text: https://journals.sagepub.com/doi/epdf/10.1177/10760296010070...